All of the characters that appeared in this episode are shown in a "fat form". Except for: Mark, Chet, Mrs. Turner, and AJ's parents. (although the latter three were most likely fat due to only sugar going down their bloodstreams)
When the majority of people became obese only three did not: Two cowboys and Mark Chang.
This is the second time Wanda shows her addiction to chocolate.
This episode could be a warning to NOT eat too much desserts.
It is unknown how Mark got the Spinach Cobbler if Timmy wished for foods on Earth to only be desserts, however it's unknown if the spinach is from Mark's planet.
Unlike most other episodes shown where Timmy will always listen to Cosmo, this time, Cosmo is ignored while Timmy and Wanda both join in the wish.
This is the second of the 3 episodes where something from outer space is heading towards Earth. The first was Pipe Down where a meteor was heading towards Earth as the second largest extinction since the ages of the dinosaurs and the third was Dumbbell Curve, only it disappeared without magic because everybody (expect Timmy) thinks it's a muffin falling from the sky
Cosmo said he is not usually the skeptical one, but he doesn't even know what it means.
This is the 100th episode of the show in total.
In this episode, it is revealed that Trixie wears a belt (which later snaps due to her enormous girth when she eats a giant cookie in the classroom).
Timmy's Mom would have appeared bouncing around the house, and Vicky would have appeared as the fattest and heaviest due to her hogging all the desserts. Both were cut for time.
Popeye the Sailor Man - Wanda's surge of energy after eating the spinach is a reference to Popeye' cutaway of eating spinach.
28 Days Later - At the cutaway, there's a time card that says "28 Days Later" which makes a reference to the movie.
Also, one part of the episode shows that the consequences of a wish causes a disaster which possible refers to the fact that in the movie the world is devastated by a disease in a short amount of time.