As a result of the negative reception revolving this episode and its implications, series creator Butch Hartman and his staff have since apologized for the unfortunate implications of the episode.
This episode is similar to a Sonic Sez episode. In the Sonic Sez episode, Coconuts becomes fed up with being Robotnik's slave and decides to quit but Sonic convinces him otherwise. Whereas, in this episode Jorgen is basically telling Timmy it's better for him to be underappreciated than to be thanked for his good deeds.
It is revealed that laughing gas has no effect on Jorgen, likely because fairies don't need to breathe. Jorgen mentioned to Timmy that laughing gas couldn't make him laugh, only pain can do that (he had faked being affected when Timmy sprayed it in his face). This is why Jorgen was already back to normal by the time Timmy had changed everything to how it was before he made his wish.
Interestingly enough, the episode never shows how the lives of three of Timmy's potential love interests, Tootie, Trixie Tang, or Veronica are affected by his never being born. This may imply that the main assertion in the episode, that the world would be better off without Timmy, is simply a method to teach a lesson and not to be taken as being true.
Butch Hartman - The fact that the Turners put their daughter "Sophia" could be a reference to Butch Hartman's daughter, "Sophia Hartman".
The World Series - In the Alternate Universe, Jorgen states that without Timmy, the Chicago Cubs win the World Series.
However, in real life, the Chicago Cubs won the World Series in 2016. Thus ending their 108-year drought of the World Series Championships.
Harvard University - In the Alternate Universe, Crocker is seen working at the "Harvard University Dimmsdale Branch". The name of the university is an obvious pun on "Harvard University".
Indiana Jones and the Raiders of the Lost Ark - In the Alternate Universe, one of Crocker's female students has the words "Love You" written on her eyelids, which references the scene where one of Indiana Jones' female students has the same thing.
Jaguar - The name of the computer Timmy gives to A.J. "XK-90" is a reference to the Jaguar XK and the fact that it was produced since late-90s.
Timmy trying to do a good deed for somebody. When that person sees it, they say "It's..." and Timmy assumes it is something positive and uses positive descriptions to see if that is what they will say. The person will however say a negative response to the deed due to something that Timmy was unaware of.
Jorgen saying "Not exactly." when Timmy believes that without him in someone's life that person's life is how he assumes it will be.
People saying "Kevin, forgive me!"
Sophia Turner is not wearing the pink hat which was bought for Timmy before he was a born when Mr. and Mrs. Turner thought they were going to have a daughter, which was seen in "The Secret Origin of Denzel Crocker!". May be justified within the context of the episode.